Essential hypertension

Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations

P. Y. Chang, Qin, L., Zhao, P., and Liu, Z. Y., “Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations”, vol. 14, pp. 17641-17650, 2015.

Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. In this study, we investigated the association between RGS5 gene variants and hypertension in the Mongolian and Han populations. Peripheral blood was obtained from 429 unrelated Mongolian herdsmen and 416 Han farmers [including essential hypertension (EH) patients and controls].

Association of NPRA and NPRC gene variants and hypertension in Mongolian population

P. Y. Chang, Liu, Z. Y., Qin, L., and Zhao, P., “Association of NPRA and NPRC gene variants and hypertension in Mongolian population”, vol. 14, pp. 18494-18502, 2015.

NPRA and NPRC are candidate susceptibility genes for essential hypertension (EH) and play a key role in the regulation of plasma levels and biological effects of natriuretic peptides. The aims of the present study were to find new genetic markers in the NPRA and NPRC genes and to assess relationships between variants and EH. A total of 797 unrelated Mongolian herdsmen were enrolled, including 389 EH patients and 408 normotensive controls. Genotyping was performed using the polymerase chain reaction/ligase detection reaction assay.

Association of TNF-α G308A gene polymorphism in essential hypertensive patients without type 2 diabetes mellitus

N. Ghodsian, Akhlaghi, M., Ramachandran, V., Heidari, F., Haghvirdizadeh, P., Eshkoor, S. A., Etemad, A., Jamaluddin, J. A., and Ismail, P., “Association of TNF-α G308A gene polymorphism in essential hypertensive patients without type 2 diabetes mellitus”, vol. 14, pp. 18974-18979, 2015.

This study aims to investigate the effects of tumor necrosis factor alpha (TNF-α) G308A gene polymorphism on essential hypertension (EHT) with or without type 2 diabetes mellitus (T2DM). The project was conducted on buccal epithelial and blood cells for case and control patients, respectively. Epithelial cells were obtained from the inner part of the cheeks. Techniques including DNA extraction, polymerase chain reaction (PCR), and restriction fragment length polymorphism (RFLP) were utilized to assess biomarkers of DNA damage.

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