estrogen

Roles of ERα and ERβ in estrogen-induced DDP chemoresistance in non-small cell lung cancer

N. Yu, Dou, L., Li, Y., Deng, L., Wei, X., Guo, Y., Yu, N., Dou, L., Li, Y., Deng, L., Wei, X., and Guo, Y., Roles of ERα and ERβ in estrogen-induced DDP chemoresistance in non-small cell lung cancer, vol. 15, p. -, 2016.

The role of estrogen in inducing chemoresistance is not yet fully understood. The objective of this study was to observe the relationship between estrogen levels and cellular response to chemotherapeutic drugs in non-small cell lung cancer (NSCLC) and to reveal the potential mechanisms involved. Cell viability was analyzed after pre-treating NSCLC cells with different levels of estrogen (E2), followed by treatment with an anti-tumor drug for 48 h. The roles of various estrogen receptors (ERs) were examined in vitro by blocking the activity of each ER individually.

Influence of the XbaI polymorphism in the estrogen receptor-α gene on human spermatogenic defects

J. Meng, Mu, X., and Wang, Y. M., Influence of the XbaI polymorphism in the estrogen receptor-α gene on human spermatogenic defects, vol. 12, pp. 1808-1815, 2013.

Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated the association between the ERα gene and PvuII and XbaI polymorphisms and the ERβ gene and RsaI and AluI polymorphisms and idiopathic male infertility in Han Chinese men.

The investigation of DNA repair polymorphisms with histopathological characteristics and hormone receptors in a group of Brazilian women with breast cancer

R. M. Dufloth, Arruda, A., Heinrich, J. K. R., Schmitt, F., and Zeferino, L. C., The investigation of DNA repair polymorphisms with histopathological characteristics and hormone receptors in a group of Brazilian women with breast cancer, vol. 7, pp. 574-582, 2008.

The association of tumor differentiation and estrogen receptor expression with the prognosis of breast cancer has been well established. Nevertheless, little is yet reported about the association of morphological characteristics of the tumor, estrogen receptor status and polymorphisms in low penetrance genes. The aim of the present study was to investigate a possible association between DNA repair gene polymorphisms (XRCC1, XPD, XRCC3, and RAD51) with histological type, grade and hormone receptor expression in a series of breast cancers.

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