Estrogen receptor

Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells

H. Zhang, Chen, F., Li, G. L., Ding, Y. Y., Tao, Z. R., Li, J. J., Zhong, S. L., and Lu, L. Z., Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells, vol. 13, pp. 1926-1937, 2014.

Estrogen regulates reproductive behavior and drives the proliferation and differentiation of several cell types. These physiological functions of estrogen are mediated by estrogen receptors (ERs), and each ER isoform plays a distinct role. To clarify the molecular mechanism of estrogen action and to evaluate the effect of ERs on the secretion of ovalbumin (OVA) in pigeon oviduct epithelial cells (POECs), we determined the complete coding sequences encoding ER alpha (ERα) and ER beta (ERβ) in pigeons.

Association of the estrogen receptor-β gene RsaI and AluI polymorphisms with human idiopathic thin endometrium

A. W. Le, Wang, Z. H., Yuan, R., Shan, L. L., Xiao, T. H., Zhuo, R., and Shen, Y., Association of the estrogen receptor-β gene RsaI and AluI polymorphisms with human idiopathic thin endometrium, vol. 12, pp. 5978-5985, 2013.

The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (controls) were included in the study. RsaI and AluI polymorphisms of the ER-β gene were analyzed with polymerase chain reaction-restriction fragment length polymorphism.

RsaI polymorphism of the ERβgene in women with endometriosis

R. C. P. C. Silva, Costa, I. R., Bordin, B. M., Silva, C. T. X., Souza, S. R., Júnior, C. L. R., Frare, A. B., and Moura, K. K. V. O., RsaI polymorphism of the ERβgene in women with endometriosis, vol. 10, pp. 465-470, 2011.

We examined the frequency of RsaI polymorphism of the ERβgene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymor­phisms of the ERβgene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG poly­morphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG.

Cross-contamination with tamoxifen induces transgene expression in non-exposed inducible transgenic mice

R. L. Brake, Simmons, P. J., and C. Begley, G., Cross-contamination with tamoxifen induces transgene expression in non-exposed inducible transgenic mice, vol. 3, pp. 456-462, 2004.

Inducible transgenic mouse models that impose a constraint on both temporal and spatial expression of a given transgene are invaluable. These animals facilitate experiments that can address the role of a specific cell or group of cells within an animal or in a particular window of time. A common approach to achieve inducibility involves the site-specific recombinase ‘Cre’, which is linked to a modified version of one of various steroid hormone-binding domains.

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