Etomidate

Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats

C. Wang, Liu, N., Li, R. - M., Zhang, Y., Shen, L., and Xiong, J. - Y., Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats, vol. 14, pp. 4740-4748, 2015.

The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis. The sepsis rat was used as a model. During glucocorticoid treatment, etomidate and propofol were applied alone or together at different time points. Survival curves, glucocorticoid receptor expression in the rat adrenal cortex, and inflammation levels were determined. The outcome of sepsis in rats was evaluated based on the combined utilization of propofol and etomidate.

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