Extracellular signal-regulated kinase

Effect of bradykinin on renal mesangial cell proliferation and extracellular matrix secretion

C. Y. Liu, Zhou, L. L., Cheng, Q., Jiang, S. N., Sheng, J., Sun, J. D., and Zhao, J. Y., “Effect of bradykinin on renal mesangial cell proliferation and extracellular matrix secretion”, vol. 13, pp. 490-498, 2014.

Recent studies have found that bradykinin (BK) plays a role in delaying glomerulosclerosis, although the mechanism of this phenomenon remains unclear. Mesangial cell proliferation (MCP) and extracellular matrix (ECM) secretion are important mechanisms for glomerulosclerosis. This study investigated the impact of BK on the platelet-derived growth factor (PDGF)-induced proliferation of mesangial cells, and evaluated its correlations with the extracellular signal-related kinase (ERK) signaling pathway.

Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes

Y. - N. Yang, Ji, W. - N., Ma, Y. - T., Li, X. - M., Chen, B. - D., Xiang, Y., and Liu, F., “Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes”, vol. 11, pp. 4672-4681, 2012.

Extracellular signal-regulated kinase (ERK1/2) is one of the mitogen-activated protein kinases, key components of the reperfusion injury salvage kinase pathway, which plays an important role in protecting the myocardium from lethal ischemia-reperfusion injury. Constitutive activation of the mitogen-activated protein kinase kinase 1 (CaMEK) can promote ERK1/2 expression, which is thereby expected to exert protective action on the heart against ischemia-reperfusion injury.

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