Familial combined hyperlipidemia

S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes

Y. - Y. Zheng, Xie, X., Ma, Y. - T., Yang, Y. - N., Fu, Z. - Y., Li, X. - M., Liu, F., Yang, S. - J., Ma, X., and Chen, B. - D., S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes, vol. 10, pp. 3256-3266, 2011.

C5L2, a G protein-coupled receptor, is known to be a functional receptor of acylation-stimulating protein, which is a stimulator of triglyceride synthesis and glucose transport. A novel C5L2 variant (S323I) was identified and its association with familial combined hyperlipidemia (FCH) was recently reported. We looked for this SNP in three Chinese ethnic groups, including Han, Uygur, and Kazakh controls and patients with FCH and type 2 diabetes.

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