Femoral head

Roles of oxidative DNA damage of bone marrow hematopoietic cells in steroid-induced avascular necrosis of femoral head

Z. Q. Zhao, Bai, R., Liu, W. L., Feng, W., Zhao, A. Q., Wang, Y., Wang, W. X., Sun, L., Wu, L. S., Cui, S. X., Zhao, Z. Q., Bai, R., Liu, W. L., Feng, W., Zhao, A. Q., Wang, Y., Wang, W. X., Sun, L., Wu, L. S., Cui, S. X., Zhao, Z. Q., Bai, R., Liu, W. L., Feng, W., Zhao, A. Q., Wang, Y., Wang, W. X., Sun, L., Wu, L. S., and Cui, S. X., Roles of oxidative DNA damage of bone marrow hematopoietic cells in steroid-induced avascular necrosis of femoral head, vol. 15, p. -, 2016.

An animal model of steroid-induced avascular necrosis of femoral head (SANFH) was established to investigate the role of oxidative DNA damage of bone marrow hematopoietic cells in SANFH. Forty-five-month-old Japanese white rabbits (male or female, 2.5 ± 0.5 kg) were randomly divided into groups A (methylprednisolone + Escherichia coli endotoxin), B (methylprednisolone alone), C (E. coli endotoxin alone), and D (blank control). The animals were sacrificed two and four weeks after administration of the last dose (N = 5 each group and each time).

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