Fibrosis

Efficient delivery of connective tissue growth factor shRNA using PAMAM nanoparticles

Z. J. Huang, Yi, B., Yuan, H., and Yang, G. P., Efficient delivery of connective tissue growth factor shRNA using PAMAM nanoparticles, vol. 13, pp. 6716-6723, 2014.

The aim of this study was to detect the anti-fibrosis activity of connective tissue growth factor (CTGF) small hairpin RNA (shRNA) mediated by polyamidoamine dendrimer nanoparticles in rat myocardial cell lines and myocardium. CTGF shRNAs were constructed from inverted oligonucleotides and a polyamidoamine nanoparticle vector was used to transfer shRNA into H9c2 myocardial cells and spontaneously hypertensive rats.

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