Filopodium

New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts

R. L. Song, Liu, X. Z., Zhu, J. Q., Zhang, J. M., Gao, Q., Zhao, H. Y., Sheng, A. Z., Yuan, Y., Gu, J. H., Zou, H., Wang, Q. C., and Liu, Z. P., New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts, vol. 13, pp. 4776-4787, 2014.

The cytoskeleton mediates various cellular processes such as differentiation and fusion, including in the filopodia and podosomes. However, apart from cell migration and formation of the sealing zone, little is known regarding the changes and related regulatory mechanisms of the cytoskeleton and additional roles of the filopodia and podosomes during the differentiation and fusion of osteoclasts. The cytomorphology and cytoskeleton of osteoclasts in the differentiation process were evaluated using tartrate-resistant acid phosphatase staining and immunofluorescence staining.

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