FOXO1 is a tumor suppressor in cervical cancer
“FOXO1 is a tumor suppressor in cervical cancer”, vol. 14, pp. 6605-6616, 2015.
, Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in cervical cancer than in cervical intraepithelial neoplasia and normal cervix by immunohistochemical analysis (P 2/M phase and upregulation of caspases-3 and -9 gene expression.