GABAAR

Study of the expression of GABAA receptor in rats during acute lung injury caused by endotoxin

L. Y. Zhan, Du, L., Xia, Z. Y., Li, W. L., and Zhao, B., Study of the expression of GABAA receptor in rats during acute lung injury caused by endotoxin, vol. 14, pp. 13312-13319, 2015.

The objective of the present study was to investigate the role of γ-aminobutyric acid type A receptor (GABAAR) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. Thirty-two male wistar rats were randomly divided into four groups. Rats in the GABA group were pretreated with LPS and GABA, while those in the bicuculline (BIC) group were pretreated with LPS and bicuculline. We assessed the arterial blood gas, dry/wet ratio, and the level of tumor necrosis factor-α (TNF-α), IL-6, malondialdehyde, and superoxide dismutase 6 h after the immunization.

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