GAD-Ab

Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus

Q. Li, Qiao, Z. R., Liu, D. B., Zeng, J. T., Zhang, J., Bo, Y., Zu, H. Y., Hu, Q., Wu, X., and Dong, S. S., “Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus”, vol. 14, pp. 3002-3009, 2015.

In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de­carboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untranslated region (rs2236418, rs185649317, and rs8190590) and type 2 diabetes and that of the healthy group were genotyped and analyzed using Sequenom MassArray SNP genotyp­ing. GAD-Ab levels were also detected.

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