Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus
“Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus”, vol. 14, pp. 3002-3009, 2015.,
In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid decarboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untranslated region (rs2236418, rs185649317, and rs8190590) and type 2 diabetes and that of the healthy group were genotyped and analyzed using Sequenom MassArray SNP genotyping. GAD-Ab levels were also detected.