Gastric cancer

Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis

Y. P. Gu, Yuan, Q. Y., Zhang, H., Wang, C. J., and Zhou, F., “Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis”, vol. 14, pp. 8375-8387, 2015.

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the correlation between the miR-146a G>C, miR-196a-2 C>T, miR-499 T>C, miRNA-27a A>G, and miRNA-149 T>C polymorphisms and the susceptibility to GC.

Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer

F. Q. Li, Xu, B., Wu, Y. J., Yang, Z. L., and Qian, J. J., “Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer”, vol. 14, pp. 739-747, 2015.

Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression between the signet-ring cell carcinoma and tubular adenocarcinoma subtypes of gastric cancer.

Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma

N. Li, Wang, H. X., Qin, C., Wang, X. H., and Han, F. Y., “Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma”, vol. 14, pp. 1404-1413, 2015.

Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor-2α (HIF-2α) plays an essential role in oxygen homeostasis. Expression of HIF-2α-inducible genes is associated with tumor progression. In this study, we investigated this correlation immunohistochemically and using quantitative reverse transcription-polymerase chain reaction to examine various clinical and pathological features in 55 specimens of gastric cancer and 40 specimens of normal gastric tissue.

c-erbB-2 expression and prognosis of gastric cancer: a meta-analysis

Z. Q. Wang and Sun, B. J., “c-erbB-2 expression and prognosis of gastric cancer: a meta-analysis”, vol. 14, pp. 1782-1787, 2015.

The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a fixed-effect model to pool hazard ratios and 95% confidence intervals from the studies.

EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population

J. H. Torres-Jasso, Marín, M. E., Santiago-Luna, E., Leoner, J. C., Torres, J., Magaña-Torres, M. T., Perea, F. J., Ibarra, B., and Sánchez-López, J. Y., “EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population”, vol. 14, pp. 1802-1807, 2015.

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>T, -191C>A, and (CA)n first intervening sequence (IVS1) have been related to EGFR overexpression and have been studied in several types of cancer, but not in gastric cancer (GC).

Comparative study of clinical efficacy of laparoscopy-assisted radical gastrectomy versus open radical gastrectomy for advanced gastric cancer

L. M. Wu, Jiang, X. J., Lin, Q. F., and Jian, C. X., “Comparative study of clinical efficacy of laparoscopy-assisted radical gastrectomy versus open radical gastrectomy for advanced gastric cancer”, vol. 14, pp. 3459-3465, 2015.

The purpose of this study is to compare the efficacy of laparoscopy-assisted radical gastrectomy (LARG) versus that of open radical gastrectomy (ORG). Clinical data of 355 patients who underwent radical gastrectomy (160 in the LARG group and 195 in the ORG group) were analyzed retrospectively. Efficacy indices were compared and analyzed between the two groups. The operating time of LARG was longer than that of ORG (228.43 ± 34.77 versus 207.59 ± 28.39 min).

Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells

Z. Y. Guo, Yao, G. D., Fu, L. P., Fu, Z. G., and Hou, B., “Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells”, vol. 14, pp. 5258-5265, 2015.

The aim of this study was to observe the effects of re­combinant human endostatin on the proliferation and apoptosis of mouse gastric cancer cells, and explore some possible mechanisms of recom­binant human endostatin inhibition of cancer. A murine gastric cancer xenograft model was established. A total of 20 mice were divided into two groups (control and experimental groups). The expression of c-Myc and basic fibroblast growth factor (bFGF) was determined by reverse transcription-polymerase chain reaction, Western blotting, and immu­nohistochemical staining methods.

Impact of enteral nutrition on postoperative immune function and nutritional status

F. Wang, Hou, M. X., Wu, X. L., Bao, L. D., and Dong, P. D., “Impact of enteral nutrition on postoperative immune function and nutritional status”, vol. 14, pp. 6065-6072, 2015.

We studied the effects of enteral nutrition (EN) support initiated 1 week before surgery on postoperative nutritional status, immune function, and inflammatory response in gastric cancer patients. A total of 200 gastric cancer patients were randomly divided into two groups: EN starting 1 week before surgery (study group) and EN starting early after surgery (control group). The two groups received EN support, following different therapeutic schedules, until the 9th day after operation.

Impact of early enteral and parenteral nutrition on prealbumin and high-sensitivity C-reactive protein after gastric surgery

B. Li, Liu, H. - Y., Guo, S. - H., Sun, P., Gong, F. - M., and Jia, B. - Q., “Impact of early enteral and parenteral nutrition on prealbumin and high-sensitivity C-reactive protein after gastric surgery”, vol. 14, pp. 7130-7135, 2015.

We investigated the impact of early enteral nutrition (EEN) and parenteral nutrition (PN) on prealbumin (PA) and high-sensitivity C-reactive protein (hs-CRP) in patients after gastric cancer surgery. Sixty-eight selected patients undergoing gastric cancer surgery were randomly divided into the EEN (N = 34) and PN (N = 34) groups. Body weight (BW), serum albumin (ALB), transferrin (TF), PA, hs-CRP, length of hospital stay, cost of postoperative nutritional support, and incidence of complications were compared between groups.

Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer

B. Li, Liu, H. Y., Guo, S. H., Sun, P., Gong, F. M., and Jia, B. Q., “Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer”, vol. 14, pp. 7136-7141, 2015.

The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa­tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group patients received conventional perioperative treatment.

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