Gastric cancer

Prognostic value of miR-141 downregulation in gastric cancer

Y. B. Lu, Hu, J. J., Sun, W. J., Duan, X. H., and Chen, X., Prognostic value of miR-141 downregulation in gastric cancer, vol. 14, pp. 17305-17311, 2015.

Previous research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer. In the present study, we investigated the clinical significance and prognostic value of miR-141 in gastric cancer. Paired tissue specimens (tumor and adjacent normal mucosa) from 95 patients with gastric cancer were obtained at the Department of General Surgery, Xiangya Hospital, Central South University from March 2009 to February 2014.

Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer

W. H. Yu, Wang, Y. X., Guo, J. Q., Wang, Y. L., Zheng, J. S., and Zhu, K. X., Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer, vol. 14, pp. 17529-17535, 2015.

We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+AA genotype of ERCC2 rs1799793 showed significant and favorable response to chemotherapy than the wide-type GG genotype in multivariate analysis (OR = 1.78, 95%CI = 1.13-2.81).

Subscribe to Gastric cancer