Gastric cancer

Genetic variability of XRCC1 influences the treatment outcome of gastric cancer

H. Q. Hu, Wang, F., Du, X., Zhao, X. Z., Jin, Z., Hou, M. X., Hu, H. Q., Wang, F., Du, X., Zhao, X. Z., Jin, Z., and Hou, M. X., Genetic variability of XRCC1 influences the treatment outcome of gastric cancer, vol. 15, p. -, 2016.

We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction fragment length polymorphism polymerase chain reaction.

Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer

W. T. Qi, Gao, J. L., and Zhang, S. S., Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer, vol. 14, pp. 13364-13369, 2015.

We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A and rs3748067C>T and IL-17F rs763780 T>C was performed using the Sequenom MassARRAY platform (Sequenom, San Diego, CA, USA) according to the manufacturer instructions.

Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis

W. G. Hu, Pan, R. J., Cai, W., Wang, Z. T., and Zhu, Z. G., Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis, vol. 14, pp. 14670-14679, 2015.

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. This case-control study involved 448 patients clinically diagnosed with gastric cancer and 372 cancer-free control individuals from China.

Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells

F. J. Ji, Tian, X. F., Liu, X. W., Fu, L. B., Wu, Y. Y., Fang, X. D., and Jin, H. Y., Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells, vol. 14, pp. 15564-15571, 2015.

The aim of the present study was to determine the anti­proliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-di­methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase, and Annexin V/propidium iodide (PI) double-staining assays. The underlying mechanisms were determined by using quanti­tative real-time polymerase chain reaction.

Serum miR-200c expression level as a prognostic biomarker for gastric cancer

H. - P. Zhang, Sun, F. - B., and Li, S. - J., Serum miR-200c expression level as a prognostic biomarker for gastric cancer, vol. 14, pp. 15913-15920, 2015.

The aim of the present study was to analyze the serum expression level of microRNA-200c (miR-200c) in gastric cancer (GC) patients and to determine the relationship between this expression and clinicopathological features and survival. Serum samples were obtained from 98 patients with GC between February 2008 and January 2013. Quantitative RT-PCR was used to assess miR-200c expression levels in serum samples. Survival curves were plotted using the Kaplan-Meier method, and differences between survival curves were compared by the log rank test.

Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients

G. Zhong, Li, H. K., Shan, T., and Zhang, N., Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients, vol. 14, pp. 17228-17234, 2015.

We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and rs3212986, and ERCC2 rs1799793 polymorphisms were conducted by the polymerase chain reaction-restriction fragment length polymorphism assay.

Prognostic value of miR-141 downregulation in gastric cancer

Y. B. Lu, Hu, J. J., Sun, W. J., Duan, X. H., and Chen, X., Prognostic value of miR-141 downregulation in gastric cancer, vol. 14, pp. 17305-17311, 2015.

Previous research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer. In the present study, we investigated the clinical significance and prognostic value of miR-141 in gastric cancer. Paired tissue specimens (tumor and adjacent normal mucosa) from 95 patients with gastric cancer were obtained at the Department of General Surgery, Xiangya Hospital, Central South University from March 2009 to February 2014.

Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer

W. H. Yu, Wang, Y. X., Guo, J. Q., Wang, Y. L., Zheng, J. S., and Zhu, K. X., Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer, vol. 14, pp. 17529-17535, 2015.

We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+AA genotype of ERCC2 rs1799793 showed significant and favorable response to chemotherapy than the wide-type GG genotype in multivariate analysis (OR = 1.78, 95%CI = 1.13-2.81).

Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Yue, X. Q., Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression, vol. 14, pp. 8117-8124, 2015.

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel invasion assay. Real-time polymerase chain reaction (PCR) was used to assess microRNA (miR)-221 expression.

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