Gene expression

Expression of PCA3 and PSA genes as a biomarker for differential diagnosis of nodular hyperplasia and prostate cancer

F. F. Coelho, F. Guimarães, L., Cabral, W. L. Ribeiro, Salles, P. G. Oliveira, E. Mateo, C., L. Nogueira, M. Nogueira e, Fonseca, C. E. Corradi, and K. Gomes, B., Expression of PCA3 and PSA genes as a biomarker for differential diagnosis of nodular hyperplasia and prostate cancer, vol. 14, pp. 13519-13531, 2015.

We evaluated the expression of the PCA3 gene in urine from patients with nodular hyperplasia/benign prostatic hyperplasia (PNH) or adenocarcinoma type prostate cancer (PCa).The study included 59 men: 22 with PCa, 26 with PNH, and 11 with no alterations (controls). Patients’ urine was collected following prostatic massage and quantified by quantitative real-time PCR for prostate cancer antigen 3 gene (PCA3) and prostate-specific antigen gene (PSA) expression with the ACTB gene for normalization.

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