Gene mutation

Clinical and genetic analyses of Chinese patients with Gitelman syndrome

M. Miao, Zhao, C. Q., Wang, X. L., Shan, Z. Y., Miao, M., Zhao, C. Q., Wang, X. L., and Shan, Z. Y., Clinical and genetic analyses of Chinese patients with Gitelman syndrome, vol. 15, p. -, 2016.

To evaluate the genotype-phenotype relationship of Gitelman syndrome in Chinese patients. We selected patients with Gitelman syndrome presenting hypokalemia. Medical history, clinical manifestations, laboratory test results, and imaging data of these patients were collected for analysis. Target gene sequencing was performed to evaluate the genotype-phenotype relationship. Gitelman syndrome was diagnosed based on medical history, clinical manifestations, laboratory test results, and imaging data.

A rare PAX6 mutation in a Chinese family with congenital aniridia

F. He, Liu, D. L., Chen, M. P., Liu, L., Lu, L., Ouyang, M., Yang, J., Gan, R., and Liu, X. Y., A rare PAX6 mutation in a Chinese family with congenital aniridia, vol. 14, pp. 13328-13336, 2015.

Aniridia is an autosomal dominant disorder characterized by the complete or partial loss of the iris and is almost associated with mutations in the paired box gene 6 (PAX6). We examined three generations of a Chinese family with congenital aniridia and observed genetic defects.

Correlation between the BRAF V600E mutation status and the clinicopathologic features of papillary thyroid carcinoma

C. L. Shi, Sun, Y., Ding, C., Lv, Y. C., and Qin, H. D., Correlation between the BRAF V600E mutation status and the clinicopathologic features of papillary thyroid carcinoma, vol. 14, pp. 7377-7385, 2015.

This study sought to investigate the correlations of V-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutations with the clinicopathologic features of papillary thyroid carcinoma and central lymph node metastasis. We retrospectively analyzed the 2-year medical records of patients who underwent surgery for papillary thyroid carcinoma. After screening, the records of 126 patients who met the study requirements were used to assess the characteristics associated with the BRAF V600E gene mutation.

Significance of sarcomere gene mutation in patients with dilated cardiomyopathy

Y. D. Li, Ji, Y. T., Zhou, X. H., Li, H. L., Zhang, H. T., Zhang, Y., Li, J. X., Xing, Q., Zhang, J. H., Hong, Y. F., and Tang, B. P., Significance of sarcomere gene mutation in patients with dilated cardiomyopathy, vol. 14, pp. 11200-11210, 2015.

Dilated cardiomyopathy (DCM) is a myocardial disease with a high mortality rate. Approximately 40 genes have been found to be associated with DCM to date. Non-familial DCM can also be caused by gene mutations, suggesting that genetic factors were involved in the pathogenesis of DCM; therefore genetic testing is beneficial for the early diagnosis of DCM, which can facilitate the implementation of preventive measures by and within patient’s families. Here, we investigated the underlying genetic mutations involved in the cause of patients with DCM.

Subscribe to Gene mutation