Genetic polymorphisms

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response

L. Yang, Wang, X. W., Zhu, L. P., Wang, H. L., Wang, B., Wu, T., Zhao, Q., JinSiHan, D. L. X. T., Wang, X. Y., Yang, L., Wang, X. W., Zhu, L. P., Wang, H. L., Wang, B., Wu, T., Zhao, Q., JinSiHan, D. L. X. T., and Wang, X. Y., Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response, vol. 15, p. -, 2016.

Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cancer (BC) chemotherapy response.

Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population

X. Z. Li, Liu, J., Shi, Y. F., Ju, D., Zhang, Y., Yue, T. F., Li, X. Z., Liu, J., Shi, Y. F., Ju, D., Zhang, Y., and Yue, T. F., Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population, vol. 15, p. -, 2016.

We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was performed to amplify the STR loci, followed by scanned electrophoresis and quantitative analysis of the fluorescence signals.

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

H. Ferreira-Fernandes, Santos, A. C. C., Motta, F. J. N., Canalle, R., Yoshioka, F. K. N., Burbano, R. R., Rey, J. A., da Silva, B. B., and Pinto, G. R., Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil, vol. 14, pp. 11710-11718, 2015.

Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-Δ32 and CCR2-V64I are related to human immunodeficiency virus infection resistance, which has led to genetic association studies for several other diseases.

Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia

A. A. Mansour, Saleh, O. M., Askar, T., Salim, A. M., and Mergani, A., Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia, vol. 14, pp. 16863-16871, 2015.

Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants that are associated with a lack of enzyme function exist at both these loci.

A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer

M. A. Proença, Fernandes, G. M. M., Russo, A., Lelis, R. B., Netinho, J. G., Cunrath, G. S., Silva, A. E., Goloni-Bertollo, E. M., and Pavarino, E. C., A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer, vol. 14, pp. 17856-17863, 2015.

Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors.

Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia

H. Y. Ren, Zhong, R., Ding, X. P., Chen, Z. Y., and Jing, Y. L., Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia, vol. 14, pp. 9261-9268, 2015.

\Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chinese Han population. We recruited 240 asthenospermic men as a patient group and 256 normospermic men as a control group, and analyzed the semen parameters on the basis of World Health Organization (WHO) guidelines.

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