Genetic risk factors

More severe clinical course of cardiovascular dysfunction in intensive care unit patients with the 894TT eNOS genotype

L. R. Fraga, Paludo, F. J. O., Bós, A. J. G., Ferraro, J. L. S., Dias, F. S., and Alho, C. S., More severe clinical course of cardiovascular dysfunction in intensive care unit patients with the 894TT eNOS genotype, vol. 12, pp. 562-568, 2013.

The endothelial nitric oxide synthase (eNOS) plays an important homeostatic role in the cardiovascular system (CVS) by maintaining appropriate blood pressure through production of nitric oxide. The 894TT genotype of 894G>T (Glu298Asp, rs1799983), a polymorphic variant of eNOS, has been associated with several vascular diseases. On the basis of this strong relationship, we monitored daily 585 critically ill adult patients according to their degree of CVS dysfunction and investigated their disease progression by the 894G>T genotype.

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