Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer
“Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer”, vol. 13, pp. 10754-10760, 2014.
, Germline mutations in identified breast cancer susceptibility genes account for less than 20% of Chinese familial breast cancers. Dicer is an essential component of the microRNA-producing machinery; germline mutations of DICER1 have been confirmed in familial pleuropulmonary blastoma, ovarian sex cord-stromal tumors, and other cancers. Low expression of DICER1 is frequently detected in breast cancer. However, whether germline mutations of DICER1 occur in familial breast cancers remain unknown.