Glucocorticoid receptor

Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats

C. Wang, Liu, N., Li, R. - M., Zhang, Y., Shen, L., and Xiong, J. - Y., Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats, vol. 14, pp. 4740-4748, 2015.

The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis. The sepsis rat was used as a model. During glucocorticoid treatment, etomidate and propofol were applied alone or together at different time points. Survival curves, glucocorticoid receptor expression in the rat adrenal cortex, and inflammation levels were determined. The outcome of sepsis in rats was evaluated based on the combined utilization of propofol and etomidate.

Tissue-specific adaptive levels of glucocorticoid receptor alpha mRNA and their relationship with insulin resistance

R. B. Castro, Longui, C. A., Faria, C. D. C., Silva, T. S., Richeti, F., Rocha, M. N., Melo, M. R., Pereira, W. L., Chamlian, E. G., and Rivetti, L. A., Tissue-specific adaptive levels of glucocorticoid receptor alpha mRNA and their relationship with insulin resistance, vol. 11, pp. 3975-3987, 2012.

Insulin resistance is an underlying cause of metabolic changes associated with cardiovascular diseases. Glucocorticoids are known determinant factors of insulin resistance. We quantified glucocorticoid receptor alpha (GRα) mRNA and 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mRNA in various tissues of 35 patients with previously established cardiovascular disease. This was a prospective study in a cardiac surgery patient setting.

Subscribe to Glucocorticoid receptor