Glucokinase

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

H. R. Frigeri, Santos, I. C. R., Réa, R. R., Almeida, A. C. R., Fadel-Picheth, C. M. T., Pedrosa, F. O., Souza, E. M., Rego, F. G. M., and Picheth, G., Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control, vol. 11, pp. 1433-1441, 2012.

Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sample of 200 pregnant women classified as healthy (control, N = 100) or with gestational diabetes (N = 100) was analyzed for mutations in the GCK gene.

Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients

R. Khalil, Al-Sheyab, F., Khamaiseh, E., Halaweh, M. A., and Abder-Rahman, H. A., Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients, vol. 8, pp. 500-506, 2009.

Maturity-onset diabetes of the young type 2 (MODY2) is a genetic form of diabetes mellitus caused by mutations in the glucokinase gene (GCK). We assessed the frequency of GCK gene mutations in Jordanian suspected MODY2 patients. We screened exons 7, 8 and 9, which are specific for pancreatic glucokinase, for mutations at positions 682A>G, p.T228A; 895G>C, p.G299R, and 1148C>A, p.S383X, respectively, in 250 subjects (100 patients suspected to have MODY2 and 150 healthy controls without family history of diabetes mellitus).

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