Glutaredoxin 1

Cardiac damage and dysfunction in diabetic cardiomyopathy are ameliorated by Grx1

X. Qi, Xu, A., Gao, Y., Shi, Y., Sun, X., Xu, J., Liu, J., Lan, Q., Chang, L., Zhang, C., Yu, H., Qi, X., Xu, A., Gao, Y., Shi, Y., Sun, X., Xu, J., Liu, J., Lan, Q., Chang, L., Zhang, C., and Yu, H., Cardiac damage and dysfunction in diabetic cardiomyopathy are ameliorated by Grx1, vol. 15, p. -, 2016.

Glutaredoxin 1 (Grx1) has been found to be an important endogenous antioxidant enzyme closely related to the pathogenesis of diabetes and cardiovascular diseases caused by oxidative stress. In this study, the functional changes of the Grx1 redox system in blood of hyperglycemic patients were examined. Furthermore, using a rat model of streptozotocin (STZ)- and high-fat-diet-induced type 2 diabetes, we explored the correlation between functional changes of the Grx1 redox system in the left ventricular tissue and blood of the diabetic rats.

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