Gαq gene promoter polymorphisms and rheumatoid arthritis in the Han Chinese population are not associated
, “Gαq gene promoter polymorphisms and rheumatoid arthritis in the Han Chinese population are not associated”, vol. 12, pp. 1841-1848, 2013.
Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activity. These indicate that Gαq plays critical roles in the pathogenesis of RA.
