GPCR

Phylogenetic analysis of Gansu sheeppox virus isolates based on P32, GPCR, and RPO30 genes

H. L. Su, Jia, H. J., Yin, C., Jing, Z. Z., Luo, X. N., and Chen, Y. X., “Phylogenetic analysis of Gansu sheeppox virus isolates based on P32, GPCR, and RPO30 genes”, vol. 14, pp. 1887-1898, 2015.

Two outbreaks of sheeppox in sheep have occurred in Gansu Province, China. The P32, GPCR, and RPO30 genes were used as markers for differential diagnosis. We confirmed that the outbreaks were caused by sheeppox virus. Sequence and phylogenetic analysis of the P32, GPCR, and RPO30 genes revealed a close relationship between the 2 isolates and Chinese sheeppox viruses.

A novel human G protein-coupled receptor is over-expressed in prostate cancer

R. B. Parmigiani, Magalhães, G. S., Galante, P. A. F., Manzini, C. V. B., Camargo, A. A., and Malnic, B., “A novel human G protein-coupled receptor is over-expressed in prostate cancer”, vol. 3, pp. 521-531, 2004.

G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily.

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