Granule cell

Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice

L. An, Liu, J., Li, W. W., Shi, Y. J., Lin, X. H., Yu, D. M., Deng, J. B., and Ren, X. Q., Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice, vol. 14, pp. 17244-17251, 2015.

LIM domain kinase 1 (LIMK1), an actin-binding kinase, can phosphorylate and inactivate its substrates, and can regulate long-term memory and synaptic plasticity. Both β-amyloid precursor protein (App) and presenilin (PS) are functional degeneration factors during early neuronal development, and are considered as potential factors that contribute to the development of Alzheimer’s disease (AD). However, hardly any information is available about the distribution and expression of LIMK1.

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