GSEA

Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis

C. Q. Yi, Ma, C. H., Xie, Z. P., Cao, Y., Zhang, G. Q., Zhou, X. K., and Liu, Z. Q., Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis, vol. 12, pp. 3136-3145, 2013.

Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We found 32 highly significant pathways, including 18 downregulated and 14 upregulated pathways associated with RA.

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