GST

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

deP. R. A. Júnior, Reis, G. Mdos, Silva, K. S. Fe, Rodrigues, D. A., Gomes, M. C. S., Martins, J. V. M., da Costa, I. R., Freitas, G. A., and Moura, K. K. V. O., Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil, vol. 14, pp. 6173-6181, 2015.

The first reports about pterygium date back to Hip­pocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascular­ized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea.

Expression and purification of GST-FHL2 fusion protein

H. Yu, Ma, Q., Lin, J., Sun, Y. F., and Zheng, F., Expression and purification of GST-FHL2 fusion protein, vol. 12, pp. 6372-6378, 2013.

Escherichia coli is the most widely used host for the production of recombinant proteins. However, most eukaryotic proteins are typically obtained as insoluble, misfolded inclusion bodies that need solubilization and refolding. The interactions between human FHL2 protein and many types of proteins, including structural proteins, kinases, and several classes of transcription factor, have been found to have important roles in a variety of fundamental processes, including arrhythmia, hypertrophy, atherosclerosis, and angiogenesis.

Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules

A. A. S. Reis, Silva, D. M., Curado, M. P., and da Cruz, A. D., Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules, vol. 9, pp. 2222-2229, 2010.

Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individuals from Goiânia city, GO, Brazil. We found no significant association of CYP1A1m1 and CYP1A1m2 genotypes with thyroid diseases (P > 0.05).

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