Guanine nucleotide-binding protein

Molecular cloning and expression analysis of the GNAS gene in pig and porcine fibroblast cells

J. Peng, Li, Y. L., Shen, Y. F., Wang, Y., and Xu, N. Y., Molecular cloning and expression analysis of the GNAS gene in pig and porcine fibroblast cells, vol. 13, pp. 5463-5473, 2014.

The Alpha subunit of the stimulatory guanine nucleotide-binding protein (GNAS) is a complex imprinted gene. The major product of the GNAS gene is the α-subunit of the guanine nucleotide-binding protein (Gas), which plays a key role in multiple signal transduction pathways. Gas is required for the production of the receptor-stimulated intracellular cyclic adenosine monophosphate (cAMP). It has been demonstrated that an increase in the concentration of the intracellular second messenger cAMP promotes apoptosis in different tumor entities.

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