Heart failure

Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis

P. Chen, Guo, L. H., Guo, Y. K., Qu, Z. J., Gao, Y., Qiu, H., Chen, P., Guo, L. H., Guo, Y. K., Qu, Z. J., Gao, Y., and Qiu, H., Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis, vol. 15, p. -, 2016.

We identified disturbed pathways in heart failure (HF) based on Gibbs sampling combined with pathway enrichment analysis. A total of 396 Markov chains (MCs) (gene count >5) were obtained. After Gibbs sampling, six differentially expressed molecular functions (DEMFs) (possibility ≥0.8) were obtained. As statistical analysis was performed on the number of individual differentially expressed genes (DEGs), we found that there were 137 DEGs with frequency of occurrence ≥2 in the DEMFs.

Correlation between protein 4.1R and the progression of heart failure in vivo

Z. Wei, Yang, G., Xu, R., Zhu, C., He, F., Dou, Q., Tang, J., Wei, Z., Yang, G., Xu, R., Zhu, C., He, F., Dou, Q., and Tang, J., Correlation between protein 4.1R and the progression of heart failure in vivo, vol. 15, p. -, 2016.

We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdominal subcutaneous injection of 5 mg⋅kg-1⋅day-1 isopropyl adrenaline to the mice for 14 days. Electrocardiography was carried out and cardiac function was assessed by ultrasonic cardiogram.

Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure

H. Y. Duan, Liu, D. M., Qian, P., Wang, S. L., Yan, L. J., Wu, J. T., Yang, H. T., Fan, X. W., and Chu, Y. J., Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure, vol. 14, pp. 15739-15748, 2015.

The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received conventional treatment, while the latter were given conventional treatment combined with atorvastatin.

Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis

J. A. Zhang, Li, J. R., and Qiao, Y. J., Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis, vol. 14, pp. 9163-9170, 2015.

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software.

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