Hepatitis B virus

Establishment of reference sequences of hepatitis B virus genotype C subgenotypes

H. L. Zhu, Wang, C. T., Xia, J. B., Li, X., and Zhang, Z. H., Establishment of reference sequences of hepatitis B virus genotype C subgenotypes, vol. 14, pp. 16521-16534, 2015.

Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. We retrieved 974 HBV/C full-length sequences from the GenBank database and subgenotyped them by phylogenetic analysis.

-173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population

Z. S. Wang, Yin, C. C., Han, S., Jiang, F. L., Guo, W. G., Wu, L. Q., and Liu, S. H., -173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population, vol. 14, pp. 8532-8538, 2015.

In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, the MIF -173G/C polymorphism may influence the immune response to HBV during natural infection.

Synonymous codon selection in the hepatitis B virus translation initiation region

M. - R. Ma, Hui, L., Wang, M. - L., Tang, Y., Chang, Y. - W., Jia, Q. - H., Yang, X. - P., Wang, X. - H., and Ha, X. - Q., Synonymous codon selection in the hepatitis B virus translation initiation region, vol. 14, pp. 8955-8963, 2015.

Hepatitis B virus (HBV) infection is a major health problem worldwide. This virus and its hosts are often fated to continual co-evolutionary interactions. Codon usage analysis has significance for studies of co-evolution between viruses, their hosts, and mRNA translation.

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