Hepatocellular carcinoma

Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats

J. Z. Gao, Wang, Y. L., Li, J., and Wei, L. X., Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats, vol. 14, pp. 671-679, 2015.

The aim of this study was to investigate the effects of the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats. Eighteen male Sprague-Dawley rats were randomly divided into normal control, model, and VEGF blocking agent groups (N = 6/group).

Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis

B. W. Yu, Zhang, L. Q., Teng, X. L., Zhang, Y., Zou, L. B., and Ying, H. Y., Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis, vol. 14, pp. 1076-1084, 2015.

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and EMBASE databases up to April 2014. We estimated the pooled odds ratio with its 95% confidence interval to assess the association using a fixed or random-effects model.

Multivariate analysis of molecular markers in peripheral blood associated with recurrence and metastasis of hepatocellular carcinoma

X. J. Liu, Wang, B., Jiang, W. G., Li, Y. J., Liu, J. B., and Zhang, M., Multivariate analysis of molecular markers in peripheral blood associated with recurrence and metastasis of hepatocellular carcinoma, vol. 14, pp. 1502-1507, 2015.

Invasion, metastasis, and recurrence are the most common causes of death in patients with hepatocellular carcinoma (HCC) and are therefore critical factors for both therapy and prognosis. Current methods for diagnosis of HCC rely mainly on serological markers such as alpha-fetoprotein and liver enzymes, together with physical assessment and imaging techniques. The availability of more accurate serum markers may facilitate screening and early diagnosis, which will improve prognosis.

Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma

D. Li, Peng, J. J., Tan, Y., Chen, T., Wei, D., Du, M., and Zhang, T., Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma, vol. 14, pp. 1926-1931, 2015.

We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism.

Effects of AFP gene silencing on Survivin mRNA expression inhibition in HepG2 cells

Z. L. Fang, Fang, N., Han, X. N., Huang, G., Fu, X. J., Xie, G. S., Wang, N. R., and Xiong, J. P., Effects of AFP gene silencing on Survivin mRNA expression inhibition in HepG2 cells, vol. 14, pp. 3184-3190, 2015.

We investigated the effects of alpha-fetoprotein (AFP) gene silencing on Survivin expression in HepG2 cells. Small interfering RNA technology was used to downregulate AFP expression in HepG2 cells. An enzyme-linked immunosorbent assay was used to measure AFP concentration in the supernatant before and after transfection. An MTT assay was used to detect cell proliferation activity before and after transfection.

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

J. Ma, Liu, Y. C., Fang, Y., Cao, Y., and Liu, Z. L., TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients, vol. 14, pp. 4461-4468, 2015.

Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, little is known regarding the relationship between TGF-β1 gene mutations and the development of hepatocellular carcinoma (HCC) in HCV-infected patients.

Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania

E. Marku, Maltese, P. E., Koni, M., Capodicasa, N., Qendro, I. S., Rigoni, E., Cecchin, S., and Bertelli, M., Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania, vol. 14, pp. 5221-5228, 2015.

Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are correlated with different disease course, severity, and response to therapy.

Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

Y. Zhao, He, H. R., Wang, M. Y., Ren, X. D., Zhang, L., Dong, Y. L., and Lu, J., Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis, vol. 14, pp. 5171-5180, 2015.

Cyclin D1 (CCND1) is a key protein involved in cell-cycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to clarify these associations. A search of the PubMed database yielded 7 relevant articles: 3 pertaining to leukemia and 4 to HCC. The odds ratios (ORs) from individual studies were pooled using a fixed or random-effect model.

Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis

Q. F. Li, Li, Q. Y., Gao, A. R., and Shi, Q. F., Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis, vol. 14, pp. 6762-6772, 2015.

Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching the Cochrane Library, CBM, EMBASE, PubMed, and the Web of Science, we tabulated and analyzed parameters from each study. Results were summarized by meta-analyses using the version 12.0 STATA software. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were also calculated in this analysis.

Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis

W. Xu, Liu, S., Li, L., Shen, Z. Y., and Wu, Y. L., Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis, vol. 14, pp. 7122-7129, 2015.

Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision re­pair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, particularly the Arg280His polymorphism. However, the data is inconsistent and incomplete.

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