Hepatocellular carcinoma

Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis

W. Xu, Liu, S., Li, L., Shen, Z. Y., and Wu, Y. L., Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis, vol. 14, pp. 7122-7129, 2015.

Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision re­pair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, particularly the Arg280His polymorphism. However, the data is inconsistent and incomplete.

Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population

X. F. Li, Chen, Y. X., Ye, W. W., Tao, X. F., Zhu, J. H., Wu, S., and Lou, L. Q., Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population, vol. 13, pp. 160-166, 2014.

The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls using the created restriction site-polymerase chain reaction method.

Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population

W. F. Xia, Ma, X. P., Li, X. R., Dong, H., and Yi, J. L., Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population, vol. 13, pp. 1314-1322, 2014.

XRCC1 (human X-ray repair complementing defective repair in Chinese hamster cell 1) gene is considered a potentially important gene influencing the risk of hepatocellular carcinoma (HCC). Our analyses detected two allelic variants of XRCC1, c.910A>G and c.1686C>G. We aimed to investigate whether these polymorphisms influence the risk of HCC. The association between the XRCC1 polymorphisms and the risk of HCC was analyzed in 719 patients and 662 controls by polymerase chain reaction-restriction fragment length polymorphism.

Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma

J. S. Wu, Chen, Y. P., Wang, L. C., Yang, Y. J., Deng, C. W., Hou, B. X., He, Z. L., and Chen, J. X., Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma, vol. 13, pp. 3812-3818, 2014.

We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms was performed in a 384-well plate format on the Sequenom MassARRAY platform.

Relationship between RUNX3 methylation and hepatocellular carcinoma in Asian populations: a systematic review

X. X. Lu, Zhu, L. Q., Pang, F., Sun, W., Ou, C., Li, Y., Cao, J., and Hu, Y. L., Relationship between RUNX3 methylation and hepatocellular carcinoma in Asian populations: a systematic review, vol. 13, pp. 5182-5189, 2014.

Runt-related transcription factor 3 (RUNX3) is a potential tumor suppressor that is frequently hypermethylated in hepatocellular carcinoma (HCC). The present meta-analysis of case-control studies was carried out to determine whether RUNX3 hypermethylation is associated with HCC. The PubMed, Embase, and Chinese National Knowledge Infrastructure databases were searched for all relevant studies published between May 2000 and May 2012.

Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population

X. H. Wang, Wang, F. R., Tang, Y. F., Zou, H. Z., and Zhao, Y. Q., Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population, vol. 13, pp. 5048-5054, 2014.

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to be smokers and drinkers, have hepatitis B and C virus infections, and a family history of cancer.

Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepatocellular carcinoma in Chinese population

Y. Y. Wan, Wang, X. W., Hui, H. X., and Wan, L., Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepatocellular carcinoma in Chinese population, vol. 13, pp. 6820-6826, 2014.

The objective of this study was to evaluate the influence of c.1564A>T genetic polymorphisms in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) susceptibility through association analysis. A total of 632 HCC patients and 645 cancer-free controls were enrolled in this study. The c.1564A>T genetic polymorphisms were genotyped by created restriction site-polymerase chain reaction (CRS-PCR) and confirmed using DNA sequencing methods.

Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population

M. F. Liu, Chen, W. Q., He, Y. Z., and Gu, Y. L., Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population, vol. 13, pp. 7184-7189, 2014.

MicroRNAs (miRNAs) are thought to play a role in cancer development. We conducted a case-control study to investigate the association between polymorphisms in miR-149C>T and hepatocellular carcinoma (HCC) risk. Duplex polymerase chain reaction with the confronting 2-pair primers were taken to genotype miR-149C>T. The association between genotype frequencies of miR-149C>T and risk of HCC was estimated as odds ratios (ORs) and 95% confidence intervals (95%CIs) using conditional regression analysis.

Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses

E. A. Samanoudy, Monir, R., Badawy, A., Ibrahim, L., Farag, K., S. Baz, E., Alenizi, D., and Alenezy, A., Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses, vol. 13, pp. 8025-8034, 2014.

Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/thymidine (T) single nucleotide polymorphism at position -1562 in the MMP-9 promoter is reported to influence the expression of the MMP-9 gene.

Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease

T. J. Xing, Jiang, D. F., Huang, J. X., and Xu, Z. L., Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease, vol. 13, pp. 7912-7918, 2014.

MicroRNA molecules have been increasingly regarded as a diagnostic and prognostic marker of certain diseases. The aim of this study was to investigate the expression and clinical significance of miR-122 and miR-29 in liver disease related to hepatitis B virus infection.

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