Hepatocyte

FGF4 and HGF promote differentiation of mouse bone marrow mesenchymal stem cells into hepatocytes via the MAPK pathway

T. Lu, Yang, C., Sun, H., Lv, J., Zhang, F., and Dong, X. J., FGF4 and HGF promote differentiation of mouse bone marrow mesenchymal stem cells into hepatocytes via the MAPK pathway, vol. 13, pp. 415-424, 2014.

Our research demonstrated the potential for mouse bone marrow mesenchymal stem cells (mBMMSCs) to differentiate into hepatocytes in vitro and in vivo. However, the exact mechanism of this process remains unknown. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) cell-signaling pathway in the differentiation of mBMMSCs into hepatocytes.

Positions of pluripotency genes and hepatocyte-specific genes in the nucleus before and after mouse ES cell differentiation

K. Udagawa and Ohyama, T., Positions of pluripotency genes and hepatocyte-specific genes in the nucleus before and after mouse ES cell differentiation, vol. 13, pp. 1979-1988, 2014.

Spatial positioning of genes in the cell nucleus plays an important role in the regulation of genomic functions. Evidence for changes in gene positioning associated with transcriptional activity has been reported. However, our understanding of this phenomenon is still quite limited.

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