HepG2 cell

Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro

M. Yue, Shen, X. J., Liu, Y. X., Lin, X. Y., Zhou, S. Q., and Song, Y. H., Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro, vol. 14, pp. 15349-15355, 2015.

Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We investigated the role of wilfortrine on liver cancer cell HepG2 apoptosis and analyzed its possible mechanisms to provide a theoretical basis for clinical analysis of liver cancer pathogenesis. The liver cancer cell line HepG2 was treated with 40 mM wilfortrine for 48 h.

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