High altitude hypoxia

Expression of aquaporin 1 and 4 in rats with acute hypoxic lung injury and its significance

Y. Wu, Pan, C. Y., Guo, C. Z., Dong, Z. J., Wu, Q., Dong, H. M., and Zhang, W., Expression of aquaporin 1 and 4 in rats with acute hypoxic lung injury and its significance, vol. 14, pp. 12756-12764, 2015.

Aquaporin (AQP)-1 and AQP-4 expression in lung tissues of SD rats during high altitude hypoxic lung injury, and the relationship between AQP-1 and AQP-4 expression, and acute hypoxic lung injury was analyzed. Thirty six healthy SD rats were divided into hypoxia 1d, 2d, 3d, 5d, and 7d groups and control group (N = 6). Pathological changes in lung tissue were observed by hematoxylin and eosin staining; lung injury was scored, and ultrastructural changes in lung tissue were observed by transmission electron microscopy.

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