High-resolution melting

Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients

H. X. Peng, Xu, X., Yang, R., Chu, Y. M., Yang, D. M., Xu, Y., Zhou, F. L., Ma, W. Z., Zhang, X. J., Guan, M., Yang, Z. H., Jin, Z. D., Peng, H. X., Xu, X., Yang, R., Chu, Y. M., Yang, D. M., Xu, Y., Zhou, F. L., Ma, W. Z., Zhang, X. J., Guan, M., Yang, Z. H., Jin, Z. D., Peng, H. X., Xu, X., Yang, R., Chu, Y. M., Yang, D. M., Xu, Y., Zhou, F. L., Ma, W. Z., Zhang, X. J., Guan, M., Yang, Z. H., and Jin, Z. D., Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients, vol. 15, p. -, 2016.

Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to describe the pathogenic association between three important MLH1 polymorphisms and SCRC in the Chinese population.

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