High-resolution melting

Association of genetic variations in the ACLY gene with growth traits in Chinese beef cattle

M. N. Li, Guo, X., Bao, P. J., Wu, X. Y., Ding, X. Z., Chu, M., Liang, C. N., Yan, P., Li, M. N., Guo, X., Bao, P. J., Wu, X. Y., Ding, X. Z., Chu, M., Liang, C. N., and Yan, P., Association of genetic variations in the ACLY gene with growth traits in Chinese beef cattle, vol. 15, p. -, 2016.

ATP citrate lyase (ACLY) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, which is a key precursor of both fatty acid and mevalonate synthesis pathways. Genetic variation of the ACLY gene may influence multiple traits associated with animal production. Here, we identified three non-synonymous mutations in ACLY exons in five beef cattle populations using DNA pool sequencing and high-resolution melting analysis.

Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients

H. X. Peng, Xu, X., Yang, R., Chu, Y. M., Yang, D. M., Xu, Y., Zhou, F. L., Ma, W. Z., Zhang, X. J., Guan, M., Yang, Z. H., Jin, Z. D., Peng, H. X., Xu, X., Yang, R., Chu, Y. M., Yang, D. M., Xu, Y., Zhou, F. L., Ma, W. Z., Zhang, X. J., Guan, M., Yang, Z. H., Jin, Z. D., Peng, H. X., Xu, X., Yang, R., Chu, Y. M., Yang, D. M., Xu, Y., Zhou, F. L., Ma, W. Z., Zhang, X. J., Guan, M., Yang, Z. H., and Jin, Z. D., Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients, vol. 15, p. -, 2016.

Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to describe the pathogenic association between three important MLH1 polymorphisms and SCRC in the Chinese population.

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