High-resolution melting analysis

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population

H. Wang, Zhao, Y., Ma, J., Zhang, G., Mu, Y., Qi, G., Fang, Z., Wang, L., Fan, Q., and Ma, Z., The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population, vol. 12. pp. 67-73, 2013.

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, that is, rs401681 at 5p15.33 and rs8034191 at 15q25, in a case-control study with 492 LC cases and 486 cancer-free controls in a Chinese population.

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