HLA

Nine polymorphic STR loci in the HLA region in the Shaanxi Han population of China

H. B. Zhang, Wei, S. G., Yu, B., Li, L., and Lai, J. H., Nine polymorphic STR loci in the HLA region in the Shaanxi Han population of China, vol. 11, pp. 2534-2538, 2012.

A large number of microsatellite genetic markers have been identified in the human leukocyte antigen (HLA) region. We investigated genetic polymorphism of the nine short tandem repeat (STR) loci (D6S276, MOGCA, D6S265, MIB, D6S273, G51152, TAP1CA, RING3CA, and D6S291) in the HLA region in the Shaanxi Han population. Using a fluorescence-labeled multiplex-PCR STR typing method, 6-13 alleles were detected in these nine STR loci in 150 unrelated Han Chinese from the region of Shaanxi, China. The distributions of the genotypes at these nine loci were in Hardy-Weinberg equilibrium.

Novel association analysis between HLA-DQB1 polymorphisms and rectal cancer based on a cross-validation design

F. Z. Tong, Yu, W. J., and Liu, H., Novel association analysis between HLA-DQB1 polymorphisms and rectal cancer based on a cross-validation design, vol. 12, pp. 5958-5963, 2013.

A new study design based on cross-validation of the age at the onset of rectal cancer and the differences between the frequency distributions of relevant genes in 2 groups was developed for identification of disease-related HLA. Patients with rectal cancer were recruited and their age at the time of the first surgery was recorded. The genetic variants of HLA-DQB1 were genotyped using an HLA-DQB1 PCR-SSP typing kit. Allele frequencies were compared with control population. The mean age of patients with and without the alleles was compared.

Genotype and phenotype correlations in diabetic patients in Uruguay

A. Mimbacas, García, L., Zorrilla, P., Acosta, M., Airaudo, C., Ferrero, R., Pena, A., Simonelli, B., Soto, E., Vitarella, G., Fernandez, J., and Javiel, G., Genotype and phenotype correlations in diabetic patients in Uruguay, vol. 8, pp. 1352-1358, 2009.

To differentiate among different types of diabetes is becoming an increasingly challenging task. We investigated whether the patient’s genetic profile is useful to identify the particular type of diabetes, to determine the corresponding hyperglycemia pathogenesis and treat accordingly. Three hundred and thirty-eight diabetic patients, diagnosed according to American Diabetes Association criteria, were recruited from 2004 to 2008 in diabetes health reference centers. We analyzed the major gene for type 1 diabetes susceptibility (HLA DQ/DR).

Association between diabetes type 1 and DQB1* alleles in a case-control study conducted in Montevideo, Uruguay

A. Mimbacas, Pérez-Bravo, F., Hidalgo, P. C., Javiel, G., Pisciottano, C., Grignola, R., Jorge, A. María, Gallino, J. Pablo, Gasagoite, J., and Cardoso, H., Association between diabetes type 1 and DQB1* alleles in a case-control study conducted in Montevideo, Uruguay, vol. 2, pp. 29-35, 2003.

We studied HLA DQB1 allele frequencies and the relative risk (RR) of various genotypes in 72 type 1 diabetic patients and 40 control individuals in Uruguay. This is a tri-racial (Caucasian, Black and Indo-American) mixed population. The products of the polymerase chain reaction amplifications were hybridized with oligonucleotides by allele-specific oligonucleotide reverse or dot blot methods. Significant differences between these two groups were observed only for allele DQB1*0302 (35%, RR = 7.34, Pvs 53%, P

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