hOGG1

Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk

D. Y. Zhong, Chu, H. Y., Wang, M. L., Ma, L., Shi, D. N., and Zhang, Z. D., Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk, vol. 11, pp. 3490-3496, 2012.

The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studies, summing 2521 cases and 2408 controls. We used odds ratios (ORs) with 95% confidence intervals (95%CIs) to assess the strength of the association.

XPD and hOGG1 gene polymorphisms in reperfusion oxidative stress

O. İsbir, Gormus, U., Ergen, H. A., Cakmakoglu, B., Kahraman, Ö. T., and Baykan, N., XPD and hOGG1 gene polymorphisms in reperfusion oxidative stress, vol. 10, pp. 3157-3162, 2011.

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD is another DNA repair gene. We investigated the effect of hOGG1 (Ser326Cys) and XPD (Lys751Gln) polymorphisms on the oxidative stress level after reperfusion.

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