Hub gene

Identification of hub genes and pathways associated with retinoblastoma based on co-expression network analysis

Q. L. Wang, Chen, X., Zhang, M. H., Shen, Q. H., and Qin, Z. M., Identification of hub genes and pathways associated with retinoblastoma based on co-expression network analysis, vol. 14, pp. 16151-16161, 2015.

The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially expressed (DE) genes, and clusters were obtained through the molecular complex detection (MCODE) algorithm. Degree centrality analysis of the co-expression network was performed to explore hub genes present in retinoblastoma.

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