hydrogen peroxide

A potential protective role for thiamine in glucose-driven oxidative stress

B. Palabiyik, F. Ghods, J., and E. Ucar, O., A potential protective role for thiamine in glucose-driven oxidative stress, vol. 13, pp. 5582-5593, 2014.

The relationship between glucose repression and the oxidative stress response was investigated in Schizosaccharomyces pombe wild type cells (972h-) and glucose repression resistant mutant type cells (ird11). We aimed to reveal the mechanism of simultaneous resistance to glucose repression and oxidative stress in ird11 mutants. Compared to the wild type, the expression of the sty1 gene was not altered in the ird11 mutant under normal growth conditions, but decreased after exposure to H2O2.

Adaptive protection against damage of preconditioning human umbilical cord-derived mesenchymal stem cells with hydrogen peroxide

D. Li, Xu, Y., Gao, C. Y., and Zhai, Y. P., Adaptive protection against damage of preconditioning human umbilical cord-derived mesenchymal stem cells with hydrogen peroxide, vol. 13, pp. 7304-7317, 2014.

Adaptive protection against damage to human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) was investigated by preconditioning with low-concentration hydrogen peroxide (H2O2) for a short-time period. Separation, culture, amplification, purification, and identification of immunophenotype and growth curve measurements of hUC-MSCs were performed in vitro. At the logarithmic phase, hUC-MSCs were incubated with different (H2O2) concentrations for 1 and 12 h, and the effects were detected by a cell metabolism assay.

Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes

L. R. S. Moreira, Miranda-Vilela, A. L., Silva, I. C. R., Akimoto, A. K., Klautau-Guimarães, M. N., and Grisolia, C. K., Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes, vol. 8, pp. 284-290, 2009.

Human haptoglobin is classified into three major phenotypes: Hp1-1, Hp2-1 and Hp2-2; there are two autosomal alleles Hp*1 and Hp*2, and the Hp*1 allele has two subtypes, Hp*1F and Hp*1S. Haptoglobin acts as an antioxidant, preventing hemoglobin-driven oxidative damage. We used the comet assay to examine oxidative damage to DNA induced by hydrogen peroxide in human leukocytes; we also looked for differences in the antioxidant capacity of haptoglobin subtypes.

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