Hyperglycemia

Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients

Z. L. Zhang, Che, X. M., Bai, Z. H., Bu, W. J., Bai, L., and Pei, H. H., Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients, vol. 13, pp. 7006-7012, 2014.

Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If blood glucose was more than 11.1 mM, a GHb test was followed within 24 h. All patients were followed up for 28 days.

Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice

Y. Wang, Zhu, Y. D., Gui, Q., Wang, X. D., and Zhu, Y. X., Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice, vol. 13, pp. 7173-7183, 2014.

In this study, we examined the effect glucagon-induced hyperglycemia on tumor growth as well as the role of the hypoxia-inducible factor 1 (HIF-1)-vascular endothelial growth factor (VEGF) pathway in this condition. A high concentration of glucose (HG) was utilized to treat HeLa cells under hypoxic or normoxic conditions, and transcriptional levels of HIF-1, VEGF, and basic fibroblast growth factor (bFGF) were evaluated. Moreover, the ability of an HIF-1 inhibitor to block the effect induced by HG was examined.

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