Hyperlipidemia

Relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effects of pravastatin in patients with hyperlipidemia

T. N. Liu, Wu, C. T., He, F., Yuan, W., Li, S. X., Li, H. W., Yu, H. Y., Wu, M., Liu, T. N., Wu, C. T., He, F., Yuan, W., Li, S. X., Li, H. W., Yu, H. Y., and Wu, M., Relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effects of pravastatin in patients with hyperlipidemia, vol. 15, p. -, 2016.

In this study, we investigated the relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effect of pravastatin in patients with hyperlipidemia. A total of 179 patients were divided into two groups: the pravastatin (N = 97) and policosanol (N = 82) treatment groups. The total cholesterol (TC), triglyceride, low-density lipoprotein (LDL-c), high-density lipoprotein, ApoA, and ApoB concentrations in the serum were measured using an automatic biochemical analyzer before and after treatment for 12 weeks.

Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats

S. M. Yang, Liu, J., and Li, C. X., Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats, vol. 13, pp. 8309-8319, 2014.

Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury is unknown. We established a hyperlipidemia model using Sprague-Dawley rats, and created a MI/R condition by ligating the cardiac left circumflex artery.

Serum lipid abnormalities are not associated with apoB 3' VNTR polymorphism in nephrotic children

P. Hu, Hu, B., Qin, Y. H., Lu, L., Li, Z. Q., Tao, L. Q., Pei, Q., and Chen, J., Serum lipid abnormalities are not associated with apoB 3' VNTR polymorphism in nephrotic children, vol. 12, pp. 765-774, 2013.

Apolipoprotein B (apoB) gene 3' variable number of tandem repeat (VNTR) is highly variable, and therefore can be an informative marker for associative analysis of lipid metabolism. This is the first report focusing on a possible association of apoB VNTR polymorphism with nephrotic hyperlipidemia. Genomic DNA was extracted from 500 children with primary nephrotic syndrome (PNS) and 500 healthy controls. The apoB genotype was determined by PCR analysis.

Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease

A. I. Güney, Ergec, D., Kırac, D., Ozturhan, H., Caner, M., Koc, G., Kaspar, C., Ulucan, K., and Agirbasli, M., Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease, vol. 12, pp. 6895-6906, 2013.

Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk factors is not well understood in CAD, likely due to the complex interrelation of genetic and environmental risk factors.

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