Hypothermia

1H-MRS before and after resuscitation following selective cerebral ultra-profound hypothermic blood flow occlusion in monkeys

X. - Q. Niu, Zhao, X. - X., Li, B. - C., Gao, Y. - J., Xu, W., Fan, Y. - D., Fu, G. - P., Wang, K., and Pu, J., 1H-MRS before and after resuscitation following selective cerebral ultra-profound hypothermic blood flow occlusion in monkeys, vol. 14, pp. 12595-12605, 2015.

We investigated the effect of selective cerebral ultra-profound hypothermic blood flow occlusion on brain tissue and cell metabolism to ascertain the efficacy and safety of selective deep hypothermic technologies using proton magnetic resonance spectroscopy (1H-MRS). The bilateral carotid artery was blocked at room temperature for 10 min. Other neck vessels were then blocked through cold perfusion of the internal carotid artery and reflux of the ipsilateral jugular vein. Thus, selective cerebral extracorporeal circulation was established.

Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury

P. Zhu, Zhao, M. Y., Li, X. H., Fu, Q., Zhou, Z. F., Huang, C. F., Zhang, X. S., Huang, H. L., Tan, Y., Li, J. X., Li, J. N., Huang, S., Ashraf, M., Lu, C., Chen, J. M., Zhuang, J., and Guo, H. M., Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury, vol. 14, pp. 10490-10499, 2015.

We evaluated changes in BAX and BCL2 expression levels after spinal cord ischemia/reperfusion injury (SCII) and hypothermia during operations in rats. Eighty rats were divided into four groups: Group A (N = 20, 18°C); Group B (N = 20, 28°C); Group C (N = 20, room temperature); and Group D (N = 20, sham operation control). Spinal cord ischemia was induced for 90 min. Hypothermia was induced 15 min before, and maintained during ischemia, followed by heating to normothermia for 30 min after reperfusion.

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