Hypoxia

A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells

Y. H. Cao, Li, D. G., Xu, B., Wang, M. Q., Zhen, N., Man, L. X., Zhang, Y. Y., Chi, M., Cao, Y. H., Li, D. G., Xu, B., Wang, M. Q., Zhen, N., Man, L. X., Zhang, Y. Y., and Chi, M., A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells, vol. 15, p. -, 2016.

Brain damage caused by perinatal asphyxia is dangerous for neonatal infants, but the mechanism by which it occurs remains elusive. In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured in vitro. Analysis of the sequence of miR-152 revealed that the phosphatase and tensin homolog gene (PTEN) is probably the target of miR-152 both in humans and rats.

Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction

Y. Y. Qiu, Chen, Y., Zeng, T. H., Guo, W. H., Zhou, W. Y., Yang, X. J., Qiu, Y. Y., Chen, Y., Zeng, T. H., Guo, W. H., Zhou, W. Y., and Yang, X. J., Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction, vol. 15, p. -, 2016.

Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined the apoptosis, caspase-3 activity, and apoptosis-associated markers in human chondrocyte cell line C28/I2 under normoxia or hypoxia.

Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

N. I. Hanafi, Mohamed, A. S., J. Noor, M., N. Hasani, A. Hamid, Siran, R., Osman, N. J., S. Rahim, A., Kadir, S. H. Sheikh Abd, Hanafi, N. I., Mohamed, A. S., J. Noor, M., N. Hasani, A. Hamid, Siran, R., Osman, N. J., S. Rahim, A., and Kadir, S. H. Sheikh Abd, Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2, vol. 15, p. -, 2016.

Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of SMases activity can promote cell survival. We hypothesized that UDCA regulates activation of ERK and Akt survival signaling pathways and SMases in protecting cardiac cells against hypoxia.

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