Hypoxia inducible factor-1α

HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies

J. Xu, Xu, L., Li, L. T., You, Q., and Cha, L. S., HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies, vol. 13, pp. 5732-5744, 2014.

Many existing studies have demonstrated that common polymorphisms in the hypoxia inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a precise estimation of the relationships between HIF1A Pro582Ser polymorphism and the risk of digestive tract cancers. We searched CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through May 1, 2013.

Common polymorphisms in the HIF-1αgene confer susceptibility to digestive cancer: a meta-analysis

J. J. Xu, Zou, L. Y., Yang, L., He, X. L., and Sun, M., Common polymorphisms in the HIF-1αgene confer susceptibility to digestive cancer: a meta-analysis, vol. 13, pp. 6228-6238, 2014.

Recent evidence suggests that common functional polymorphisms in the hypoxia inducible factor-1α (HIF-1α) gene may play an important role in the development and progression of digestive cancer, but individually published results are inconclusive. Our meta-analysis is aimed to derive a more precise estimation of the relationships between HIF-1αgene polymorphisms and digestive cancer risk.

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