Hypoxia-inducible factor-2α

Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma

N. Li, Wang, H. X., Qin, C., Wang, X. H., and Han, F. Y., “Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma”, vol. 14, pp. 1404-1413, 2015.

Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor-2α (HIF-2α) plays an essential role in oxygen homeostasis. Expression of HIF-2α-inducible genes is associated with tumor progression. In this study, we investigated this correlation immunohistochemically and using quantitative reverse transcription-polymerase chain reaction to examine various clinical and pathological features in 55 specimens of gastric cancer and 40 specimens of normal gastric tissue.

Hypoxia-inducible factor-2α (HIF-2α) mediates the effects of hypoxia on the promotion of HeLa cell viability, colony formation, and invasion capacity in vitro

J. Xiong, Zhu, F. F., and Nie, M. F., “Hypoxia-inducible factor-2α (HIF-2α) mediates the effects of hypoxia on the promotion of HeLa cell viability, colony formation, and invasion capacity in vitro”, vol. 14, pp. 3281-3292, 2015.

Hypoxia reduces the oxygen supply to tumor cells and may limit tumor cell growth. However, hypoxia promotes tumor cell metabolic adaptation, apoptosis resistance, angiogenesis, invasion, and metastasis. Hypoxia-inducible factor-2α (HIF-2α) may be responsible for these hypoxia-induced changes. In this study, we investigated the effects of hypoxia and HIF-2α knockdown in HeLa cells. HIF-2α shRNA lentivirus was used to knock down HIF-2α expression; cell viability, colony formation, invasion capacity, and gene expression were assessed.

HIF-2α as a prognostic marker for breast cancer progression and patient survival

H. X. Wang, Qin, C., Han, F. Y., Wang, X. H., and Li, N., “HIF-2α as a prognostic marker for breast cancer progression and patient survival”, vol. 13, pp. 2817-2826, 2014.

Malignant cells show increased invasion potency in vitro and in vivo. This process is considered to be mediated by matrix-metalloproteases (MMPs). Hypoxia-inducible factor-2α (HIF-2α) may upregulate MMP-2 expression; however, little is known about the correlation between HIF-2α and MMP-2 expressions in breast cancer. The current study investigated this correlation immunohistochemically according to various clinical and pathological features in 102 paraffin-embedded archival tissue block specimens from patients with breast cancer.

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