IL-1β

Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors

B. X. Ren, Ji, Y., Tang, J. C., Sun, D. P., Hui, X., Yang, D. Q., and Zhu, X. L., Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors, vol. 14, pp. 2133-2138, 2015.

The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshinone IIA + Sham, DMSO + Tumor, and Control groups. Paw withdrawal thermal latency (PWTL) was measured with a radiant heat stimulus and mRNA expression levels were determined using real-time PCR.

Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis

R. T. Sun, Tian, W. J., Xing, X. W., Gao, S. H., and Wang, S. B., Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis, vol. 14, pp. 6859-6864, 2015.

The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1βrs16944, IL8 rs4073, IL10 rs1800872, and IL10 rs1800896 was carried out using a 384-well plate format on the Sequenom MassARRAY platform.

Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice

R. L. Sun, Wang, H. Y., Yang, X. Y., Sheng, Z. J., Li, L. M., Wang, L., Wang, Z. G., and Fei, J., Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice, vol. 10, pp. 3712-3721, 2011.

Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Krüppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan.

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